Saturday, June 2, 2012

Marriage Isn't A Game ? Simple Business Solutions

Since you?ve finally found the perfect person with whom you desire to spend the rest of your days, the next thing that you should worry about is how to romantically propose to that person. As soon as she already gave you her sweet ?Yes, I will marry you,? the next thing to do is to plan for the wedding. This occasion is definitely special for both of you since it is the day when you will face God and have your relationship be blessed by Him.

Nowadays, marriage is taken lightly by everybody. A lot of people see marriage to be a convenient way of being with the person however, when disaster or a big problem hits them, they will easily file for a divorce. Most of married couples will in some way face trials in their relationships and if love is not in the matrimony, expect the relationship not to last.

It is actually neither the wedding that matters nor is it the expensive honeymoon that matters. What matter most in almost any relationship is forgiveness each time a partner commits a mistake along with the heart of understanding for the partner?s shortcomings in the relationship. Only a few relationship is perfect and honestly, just about 1% of married couples will state that their marriage is a perfect one. The reason being no person is perfect ? each one of us has flaws and faults. Nonetheless, this absolutely should not also be given as an excuse for hurting your spouse.

Try to examine yourself, and if there are any issues that you need to fix, then do not delay if you really want to make your relationship last and avoid getting into a nasty divorce. To be able to help you deal with your problems, consult a professional. In order to fix your marriage later on, it is important that you address personal issues first.

One of the reasons why couples split is lack of time and effort from both spouses to work out the relationship. A lot of people think that marriage is like ordering a past ? if you do not like the taste of it, you can dump it. Well, this is not how it works. Marriage isn?t merely a contract between a man and a woman but it is a covenant binding yourself, your significant other, and God.

You need to do the necessary undertakings in case you are having problems with your relationship. Take big steps to be able to resolve the problems in the relationship. Consult a marriage counselor, whenever needed.

The accessibility of St Louis Reception Venues allows guests to attend your bridal shower without having to waste extra gas on the road. Celebrate a fun-filled and memorable party and be amazed by the magnificent scenery that can be found in the view of St Louis banquet rooms.

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Wisconsin research team reveals novel way to treat drug-resistant brain tumor cells

Wisconsin research team reveals novel way to treat drug-resistant brain tumor cells [ Back to EurekAlert! ] Public release date: 1-Jun-2012
[ | E-mail | Share Share ]

Contact: Susan Lampert Smith
ssmith@uwhealth.org
608-262-7335
University of Wisconsin-Madison

MADISON New research from the University of Wisconsin-Madison explains why the incurable brain cancer, glioblastoma multiforme (GBM), is highly resistant to current chemotherapies.

The study, from the brain-tumor research lab of Dr. John Kuo, assistant professor of neurological surgery and human oncology at UW School of Medicine and Public Health, also reports success for a combination therapy that knocks out signaling of multiple members of the epidermal growth factor receptor (EGFR) family in brain-cancer cells.

The late U.S. Sen. Edward M. Kennedy died of GBM in 2009. People diagnosed with GBM live on average for only 15 months after diagnosis, even after undergoing aggressive surgery, radiation and chemotherapy. Earlier research from Dr. Kuo and other scientists showed that GBM cancer stem cells escape current treatments and proliferate rapidly to cause tumor recurrence.

Several years ago, research suggested that a drug engineered to target EGFR signaling might work against GBM because many brain cancers carried EGFR mutations. Excessive and abnormal EGFR signaling spurs the growth of cancer cells. Although cetuximab, a monoclonal-antibody drug, was successful in clinical trials for patients with lung, colorectal, and head and neck cancers, it failed against GBM.

Research by Dr. Paul Clark, a scientist in Kuo's lab and the study's lead author, shows why. When cetuximab treatment switches off EGFR activity and should inhibit cancer-cell growth, cancer stem cells compensate by turning on two other EGFR family receptors (ERBB2 and ERBB3) and continue to grow. One of these receptors, ERBB2, is implicated in certain types of chemotherapy-resistant breast cancer. Fortunately, another novel drug already approved by the FDA, lapatinib, inhibits ERBB2 activity and signaling by multiple EGFR members.

This study shows that cancer stem-cell growth was markedly inhibited by lapatinib treatment, which results in combined knockout of multiple EGFR family members.

"This is good news, because these drugs target an important mechanism for the (GBM) cancer cells to grow so quickly and evade current therapies, and these molecularly targeted drugs are also well-tolerated by patients and have minimal side effects," Dr. Clark said.

Kuo, director of the Comprehensive Brain Tumor Program at UW Health and chair of the Carbone Cancer Center brain tumor group, said that results of several brain cancer clinical trials with these novel drugs and other new strategies are pending or underway.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Wisconsin research team reveals novel way to treat drug-resistant brain tumor cells [ Back to EurekAlert! ] Public release date: 1-Jun-2012
[ | E-mail | Share Share ]

Contact: Susan Lampert Smith
ssmith@uwhealth.org
608-262-7335
University of Wisconsin-Madison

MADISON New research from the University of Wisconsin-Madison explains why the incurable brain cancer, glioblastoma multiforme (GBM), is highly resistant to current chemotherapies.

The study, from the brain-tumor research lab of Dr. John Kuo, assistant professor of neurological surgery and human oncology at UW School of Medicine and Public Health, also reports success for a combination therapy that knocks out signaling of multiple members of the epidermal growth factor receptor (EGFR) family in brain-cancer cells.

The late U.S. Sen. Edward M. Kennedy died of GBM in 2009. People diagnosed with GBM live on average for only 15 months after diagnosis, even after undergoing aggressive surgery, radiation and chemotherapy. Earlier research from Dr. Kuo and other scientists showed that GBM cancer stem cells escape current treatments and proliferate rapidly to cause tumor recurrence.

Several years ago, research suggested that a drug engineered to target EGFR signaling might work against GBM because many brain cancers carried EGFR mutations. Excessive and abnormal EGFR signaling spurs the growth of cancer cells. Although cetuximab, a monoclonal-antibody drug, was successful in clinical trials for patients with lung, colorectal, and head and neck cancers, it failed against GBM.

Research by Dr. Paul Clark, a scientist in Kuo's lab and the study's lead author, shows why. When cetuximab treatment switches off EGFR activity and should inhibit cancer-cell growth, cancer stem cells compensate by turning on two other EGFR family receptors (ERBB2 and ERBB3) and continue to grow. One of these receptors, ERBB2, is implicated in certain types of chemotherapy-resistant breast cancer. Fortunately, another novel drug already approved by the FDA, lapatinib, inhibits ERBB2 activity and signaling by multiple EGFR members.

This study shows that cancer stem-cell growth was markedly inhibited by lapatinib treatment, which results in combined knockout of multiple EGFR family members.

"This is good news, because these drugs target an important mechanism for the (GBM) cancer cells to grow so quickly and evade current therapies, and these molecularly targeted drugs are also well-tolerated by patients and have minimal side effects," Dr. Clark said.

Kuo, director of the Comprehensive Brain Tumor Program at UW Health and chair of the Carbone Cancer Center brain tumor group, said that results of several brain cancer clinical trials with these novel drugs and other new strategies are pending or underway.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Everyone Outdoors: Summer Opportunities with Northeast Passage!

RECREATION OPPORTUNITIES abound with this exceptional adaptive recreation organization!!!!
Water Ski on Tuesday evenings! Fee: $20/Session Two locations: Attitash Lake in Merrimac, MA on June 12, 19, July 10, 24, Aug 7, 14 Swains Lake in Barrington, NH on June 26, July 17, 31, Aug 21, 28 Waterski Weekend: Fee: $20/day -- Sign up for one or both days! August 11 & 12 in Mashpee, MA Essential Eligibility Requirement: Participants must be able to turn themselves from face down to face up in the water, while wearing a PFD (life jacket). Instruction on how to do this can be provided. Please contact NEP in advance if you are concerned or have questions. Disabled Sports USA 'I Can Do Anything' Youth Scholarships Available! The Disabled Sports USA ?I Can Do Anything!? Youth Adaptive Sports Scholarship! This initiative provides funding for youth with disabilities (under 18), with limited financial means, to participate in adaptive sports programs. By filling out the application, your child can receive a scholarship for the event registration fees, transportation and lodging costs! This scholarship is good for ANY NEP program between now and September! Contact NEP at 603-862-0070 or northeast.passage@unh.edu to receive an application. Cycling at Acadia National Park, Maine! Date: June 16, 2012 Time: All Day Ride Acadia National Park in Bar Harbor, ME. Meet NEP there to rent your adaptive cycle and spend the weekend riding the 45 miles of historic carriage roads! NEP Cycle Rental Fee: $25/day. Summer Equipment Rentals! What do you do when you want to play but don?t have the toys? YOU RENT! NEP's equipment rental program makes it affordable to try before you buy, be a weekend warrior, gain skills, and be involved in more than one sport. Best of all, you get the choice and freedom you deserve. What are you waiting for? Contact NEP to reigster for programs and reserve rental equipment. You can even rent waterskis! Call 603-862-0070 or email northeast.passage@unh.edu. Pre-registration is required for all programs and payment is required at the time of booking to hold your spot. Space is limited, so register soon!

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Friday, June 1, 2012

Bush portraits unveiled at White House; Obama is ?congenial? (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

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Clint Eastwood is 82! Vote for his best film

By Brett Malec, E! Online

Lucas Jackson / Reuters file

Oscar-winning actor and director Clint Eastwood is turning 82 years old today.

But don't even think of getting the "Million Dollar Baby" director a birthday gift.

READ: 'Mrs. Eastwood & Company' Stars Talk Kardashians and Justin Timberlake

"Clint does not do holidays or gifts," his wife and E! reality star?Dina Eastwood recently told us. "So if you don't give him a gift he gives you a big kiss and says, 'Thank you so much for not giving me a gift.'"

"Fans send him gifts, we don't," his daughter Francesca said.

PHOTOS: Clint Eastwood: Movie Star!

But the "Mrs. Eastwood & Company" star is getting her famous father something. "A phone call," Francesca said. "'Hi, happy birthday,' and here's a pair of socks."

This YouTube compilation captures 170 classic Clint Eastwood lines. Check it out and vote below for your favorite Clint film. And head over to Facebook to discuss the man and the movies.

What's your favorite Clint Eastwood movie?

"The Outlaw Josey Wales"

?

24.1%

(6,571 votes)

"Unforgiven"

?

18.5%

(5,063 votes)

"Dirty Harry"

?

16%

(4,374 votes)

"Gran Torino"

?

15.9%

(4,334 votes)

"The Bridges of Madison County"

?

5.9%

(1,605 votes)

"Million Dollar Baby"

?

5.6%

(1,526 votes)

"Play Misty For Me"

?

4%

(1,094 votes)

Other (discuss on Facebook)

?

3.9%

(1,064 votes)

"Heartbreak Ridge"

?

3.9%

(1,056 votes)

"Every Which Way But Loose"

?

2.3%

(628 votes)

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China 'detains hundreds' in Tibet capital

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Google's Steve Lee talks about the history and future of Project Glass

Google's Steve Lee talks about the history and future of Project Glass

Details on Google's Project Glass haven't been the easiest thing to come by since the wearable computing effort was announced earlier this year, but Google execs have been getting a bit more talkative and eager to give demonstrations as of late. You can now add product lead Steve Lee to that list, who's given a fairly wide-ranging interview to Fast Company on the project's origins and its future. Not surprisingly, he confirmed that the early prototypes were a fair bit bulkier -- starting a laptop in a backpack -- and that even the current prototypes are still "very early," although they do handle more than just photos (he gives Maps as one example). Lee does see photo-taking as a "key aspect" to the device, though.

He also cast some doubt on initial reports that the devices would be available this year for between $250 and $600, saying that would be "pretty aggressive timing," but he also noted that he "wouldn't be on this project if it was like a five-year endeavor." As for the future, he says that contact lenses with the technology is a natural evolution but a definite "long-term thing," and that a nearer term goal is to "serve everyone and make this is a universal device," adding that they've "prototyped lots of different form factors to accommodate all those folks." All of that comes just from the first part of a two-part interview, though -- the rest is promised later this week.

Google's Steve Lee talks about the history and future of Project Glass originally appeared on Engadget on Wed, 30 May 2012 16:12:00 EDT. Please see our terms for use of feeds.

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