The Dow jumped 89 points to close at 12805, a stark turnaround from yesterday's free-fall.
Investors on Wednesday all but forgot the previous day's burdens and sent stocks soaring. It was a stark turnaround from the day before, when they'd pushed the market into a free-fall on worries about European debt and corporate earnings in the U.S.
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Those fears about problems festering on both sides of the Atlantic were calmed thanks to a surprising profit from Alcoa and news that borrowing costs in Spain had edged down, a potential sign that investors have more faith ? for now, anyway ? in that country's financial health.
The result was a U-turn on Wall Street. The Dow Jones industrial average climbed as much as 129 points in early trading before settling at 12,805.39, up 89.46 points. The previous day, it had lost 214 points, the cap to its biggest and longest losing streak this year.
European markets rose, too. Stocks climbed roughly 1 percent in major capitals, excluding Greece, after losing 2 to 3 percent the day before. Treasury prices fell, signaling that investors are more willing to put money in stocks.
Other U.S. indexes also erased much of the previous day's losses. The Standard & Poor's 500 rose 10.12 points to 1,368.71 after losing 24 points the day before. The Nasdaq composite climbed 25.24 points to 3,016.46 following a 56-point loss Tuesday.
Alcoa rose more than 6 percent after reporting late Tuesday that it turned a profit in the first three months of the year and handily beat the expectations of Wall Street analysts, who were predicting a loss. Since Alcoa is the first company in the Dow average to report earnings, its results have a greater ability to move the market compared with companies that report later. More first-quarter results will be released over the next few weeks.
Market watchers were divided over how long the gains would last and whether Alcoa's profits actually mean anything for the rest of the earnings season.
"I'm not predicting we're going to have a blowout earnings quarter," said David Armstrong, managing director of Monument Wealth Management in Alexandria, Virginia. "But I think if people thought earnings season was going to be bad, they may be pleasantly surprised."
"One earnings report?" countered Uri Landesman, president of the New York hedge fund Platinum Partners. The boost "will last until the first bad number."
Among stocks making big moves:
?Titan Machinery, which sells agricultural and construction equipment, jumped nearly 17 percent after reporting a big increase in quarterly profit.
?Cell phone maker Nokia plummeted nearly 16 percent after warning that heavy competition will hurt first-quarter results.
Every day on the crowdSPRING Twitter account and on my own Twitter account, I post links to posts or videos I enjoyed reading or viewing. These posts and videos are about logo design, web design, startups, entrepreneurship, small business, leadership, social media, marketing, and more! Here are some of the links that I?ve liked and shared this past week!
The image above shows the amount of caffeine in various types of coffee and tea. More interesting facts about the health benefits (and risks) of tea and coffee in the Other section below.
Fall In Love With Your Business, Not Your Business Plan ? http://bit.ly/H5aib0
Design is Marketing ? http://bit.ly/I0QCUz
The Dirty Little Secret Of Overnight Successes ? http://bit.ly/HfUrro
How much does Pinterest actually make? ? http://bit.ly/H59xyN
Design is Marketing ? http://bit.ly/I0QCUz
Forget Self-Improvement ? http://bit.ly/H59Vxk
The Education of Google?s Larry Page ? http://buswk.co/HoYgHC
Fall In Love With Your Business, Not Your Business Plan ? http://bit.ly/H5aib0
Some Thoughts about Selling at Startups ? http://bit.ly/H36Mu6
The Dirty Little Secret Of Overnight Successes ? http://bit.ly/HfUrro
Study: How one dresses impacts how they perform ? http://bit.ly/I0R0lP
Getting the Feedback You Need To Raise Capital: Thick Skin Needed ? http://bit.ly/Hi4Ay0
Eye Movement Study Reveals Six Must-Know Things About Facebook Brand Pages ? http://rww.to/HVnEms
Design is Marketing ? http://bit.ly/I0QCUz
Interesting case study of what happened when Pepsi gutted its advertising ? http://bit.ly/H7Yncs
More on Pepsi?s market slide (with useful insight about ad strategy) ? http://bit.ly/H7YtkA
30 Attractive Rounded Fonts to Download ? http://bit.ly/HPC0qU
40 Stylish Fonts For Professional Web And Print Design ? http://bit.ly/HWBmDV
Redesigning With Personality ? http://bit.ly/HESUKQ
Drop Caps: Historical Use And Current Best Practices With CSS ? http://bit.ly/HkF1PT
30 inspiring calligraphy works ? http://bit.ly/HPJYCo
Design is Marketing ? http://bit.ly/I0QCUz
30 Examples of Innovative Packaging Designs ? http://bit.ly/Hx62uQ
Color and Emotion: What Does Each Hue Mean? ? http://bit.ly/HczGwb
30 Excellent Pixel Art Tutorials For Pixel Lovers ? http://bit.ly/HgATTJ
Mobile UI Design Patterns: 10+ Sites for Inspiration ? http://bit.ly/HDJ6KX
How to Design a User-Interface Element in Photoshop ? http://bit.ly/HkF3av
Big advance against cystic fibrosisPublic release date: 5-Apr-2012 [ | E-mail | Share ]
Contact: Kory Dodd kdodd1@partners.org 617-726-0274 Massachusetts General Hospital
Stem cell researchers create lung surface tissue in a dish
Harvard stem cell researchers at Massachusetts General Hospital (MGH) have taken a critical step in making possible the discovery in the relatively near future of a drug to control cystic fibrosis (CF), a fatal lung disease that claims about 500 lives each year, with 1,000 new cases diagnosed annually.
Beginning with the skin cells of patients with CF, Jayaraj Rajagopal, MD, and colleagues first created induced pluripotent stem (iPS) cells, and then used those cells to create human disease-specific functioning lung epithelium, the tissue that lines the airways and is the site of the most lethal aspect of CF, where the genes cause irreversible lung disease and inexorable respiratory failure.
That tissue, which researchers now can grow in unlimited quantities in the laboratory, contains the delta-508 mutation, the gene responsible for about 70 percent of all CF cases and 90 percent of the ones in the United States. The tissue also contains the G551D mutation, a gene that is involved in about 2 percent of CF cases and the one cause of the disease for which there is now a drug.
The work is featured on the cover of this month's Cell Stem Cell journal, which appeared online today. Postdoctoral fellow Hongmei Mou, PhD, is first author on the paper, and Rajagopal is the senior author.
Mou credits learning the underlying developmental biology in mice as the key to making tremendous progress in only two years. "I was able to apply these lessons to the iPS cell systems," she said. "I was pleasantly surprised the research went so fast, and it makes me excited to think important things are within reach. It opens up the door to identifying new small molecules [drugs] to treat lung disease."
Doug Melton, PhD, co-director of the Harvard Stem Cell Institute (HSCI http://www.hsci.harvard.edu/), said, "This work makes it possible to produce millions of cells for drug screening, and for the first time human patients' cells can be used as the target." Melton, who is also co-chair of Harvard's inter-School Department of Stem Cell and Regenerative Biology and is the Xander University Professor, added, "I would expect to see rapid progress in this area now that human cells, the very cells that are defective in the disease, can be used for screening."
Rajagopal said, "The key to our success was the ecosystem of the Harvard Stem Cell Institute and MGH. HSCI investigators pioneered the strategies we used, helped us at the bench, and gave us advice on how to combine our knowledge of lung development with their exciting new platforms. Indeed, we also enjoyed a wonderful collaboration with Darrell Kotton's lab at Boston University that was able to convert mouse cells into lung tissue. These interactions really helped fuel us ahead."
The epithelial tissue created by Rajagopal and his colleagues at the MGH Center for Regenerative Medicine (http://www.massgeneral.org/regenmed/) also provides researchers with the same cells that are involved in a number of common lung conditions, including asthma, lung cancer, and chronic bronchitis, and may hasten the development of new insights and treatments into those conditions as well.
"We're not talking about a cure for CF; we're talking about a drug that hits the major problem in the disease. This is the enabling technology that will allow that to happen in a matter of years," said Rajagopal, a Harvard Medical School assistant professor of Medicine.
Also a physician trained as a pulmonologist, the specialty that treats CF patients, Rajagopal said, "When we talk about research and advances, donors and patients ask: 'When? How soon?' And we usually hesitate to answer. But we now have every single piece we need for the final push. So I have every hope that we'll have a therapy in a matter of years."
Cystic fibrosis, which used to claim its victims in infancy or early childhood, has evolved into a killer of those in their 30s because treatments of the infections that characterize the disease have improved. But despite those advances, there has been little progress in treating the underlying condition that affects the vast majority of patients: a defect in a single gene that interferes with the fluid balance in the surface layers of the airways and leads to a thickening of mucus, difficulty breathing and repeated infections and hospitalizations.
The discovery and recent FDA approval of the drug Ivacaftor, which corrects the G551D defect seen in about 2 percent of CF patients, has served as a proof of concept to demonstrate that the disease can be attacked with a conventional molecular treatment. In fact, Ivacaftor was found by screening thousands of drugs on a far less than ideal cell line. In the end, many drugs that functioned well on this cell line proved ineffective when used on genuine human airway tissue.
Genuine human airway tissue is the gold standard prior to drugs being tested clinically, but it has been extremely difficult to obtain the tissue from patients, and when it could be obtained, the tissue rarely survived long in the lab all of which created a major bottleneck in screening for a therapy. But by creating iPS cells that contain the entire genome of a CF patient and directing those cells to develop into lung progenitor cells, which then develop into epithelium, the group appears to have solved this key problem.
Rajagopal, who did his own postdoctoral fellowship in Melton's laboratory during the first half of the past decade after completing his training in pulmonary medicine, said that having both the G551D and 508 genes in the epithelial tissue provides a way to prove that the tissue will be effective in testing drugs against CF.
"We've created the perfect cell line to show that the drug out there that works against G551D mutation works in this system, and then we're in business to screen for a drug against delta 508," he said. "We'll know soon that the cell line works. We know it makes bonafide airway epithelium, and we'll have the proof of principle that the tissue responds properly to the only known drug. We think this is the near-ideal tissue platform to find a drug for the majority of CF."
Rajagopal's lab has created numerous other cell lines to further show that a CF drug that works in one patient should work in others and to see whether this will be an area that allows a more personalized approach to medicine.
"I'm most looking forward to working with the community of pulmonologists that concentrate in CF to generate therapies. This is occurring more than two decades after the remarkable work that identified the CF gene. Looking forward, I'm very excited that CF may lead the way in lung disease once more, by demonstrating that our iPS platform can be used to probe the diseases that are much less well understood. CF has more than two decades of great biology behind it. The reason we chose to attack this disease first was because of that pioneering work that lets us use our system with a very firm foundation," Rajagopal said.
###
The Harvard Stem Cell Institute is a collaborative of more than 1000 scientists throughout Harvard and its affiliated hospitals and Institutes, dedicated to using the fruits of stem cell biology to advance cures and treatments for human diseases and the degeneration associated with aging.
Massachusetts General Hospital (www.massgeneral.org), founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $750 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Big advance against cystic fibrosisPublic release date: 5-Apr-2012 [ | E-mail | Share ]
Contact: Kory Dodd kdodd1@partners.org 617-726-0274 Massachusetts General Hospital
Stem cell researchers create lung surface tissue in a dish
Harvard stem cell researchers at Massachusetts General Hospital (MGH) have taken a critical step in making possible the discovery in the relatively near future of a drug to control cystic fibrosis (CF), a fatal lung disease that claims about 500 lives each year, with 1,000 new cases diagnosed annually.
Beginning with the skin cells of patients with CF, Jayaraj Rajagopal, MD, and colleagues first created induced pluripotent stem (iPS) cells, and then used those cells to create human disease-specific functioning lung epithelium, the tissue that lines the airways and is the site of the most lethal aspect of CF, where the genes cause irreversible lung disease and inexorable respiratory failure.
That tissue, which researchers now can grow in unlimited quantities in the laboratory, contains the delta-508 mutation, the gene responsible for about 70 percent of all CF cases and 90 percent of the ones in the United States. The tissue also contains the G551D mutation, a gene that is involved in about 2 percent of CF cases and the one cause of the disease for which there is now a drug.
The work is featured on the cover of this month's Cell Stem Cell journal, which appeared online today. Postdoctoral fellow Hongmei Mou, PhD, is first author on the paper, and Rajagopal is the senior author.
Mou credits learning the underlying developmental biology in mice as the key to making tremendous progress in only two years. "I was able to apply these lessons to the iPS cell systems," she said. "I was pleasantly surprised the research went so fast, and it makes me excited to think important things are within reach. It opens up the door to identifying new small molecules [drugs] to treat lung disease."
Doug Melton, PhD, co-director of the Harvard Stem Cell Institute (HSCI http://www.hsci.harvard.edu/), said, "This work makes it possible to produce millions of cells for drug screening, and for the first time human patients' cells can be used as the target." Melton, who is also co-chair of Harvard's inter-School Department of Stem Cell and Regenerative Biology and is the Xander University Professor, added, "I would expect to see rapid progress in this area now that human cells, the very cells that are defective in the disease, can be used for screening."
Rajagopal said, "The key to our success was the ecosystem of the Harvard Stem Cell Institute and MGH. HSCI investigators pioneered the strategies we used, helped us at the bench, and gave us advice on how to combine our knowledge of lung development with their exciting new platforms. Indeed, we also enjoyed a wonderful collaboration with Darrell Kotton's lab at Boston University that was able to convert mouse cells into lung tissue. These interactions really helped fuel us ahead."
The epithelial tissue created by Rajagopal and his colleagues at the MGH Center for Regenerative Medicine (http://www.massgeneral.org/regenmed/) also provides researchers with the same cells that are involved in a number of common lung conditions, including asthma, lung cancer, and chronic bronchitis, and may hasten the development of new insights and treatments into those conditions as well.
"We're not talking about a cure for CF; we're talking about a drug that hits the major problem in the disease. This is the enabling technology that will allow that to happen in a matter of years," said Rajagopal, a Harvard Medical School assistant professor of Medicine.
Also a physician trained as a pulmonologist, the specialty that treats CF patients, Rajagopal said, "When we talk about research and advances, donors and patients ask: 'When? How soon?' And we usually hesitate to answer. But we now have every single piece we need for the final push. So I have every hope that we'll have a therapy in a matter of years."
Cystic fibrosis, which used to claim its victims in infancy or early childhood, has evolved into a killer of those in their 30s because treatments of the infections that characterize the disease have improved. But despite those advances, there has been little progress in treating the underlying condition that affects the vast majority of patients: a defect in a single gene that interferes with the fluid balance in the surface layers of the airways and leads to a thickening of mucus, difficulty breathing and repeated infections and hospitalizations.
The discovery and recent FDA approval of the drug Ivacaftor, which corrects the G551D defect seen in about 2 percent of CF patients, has served as a proof of concept to demonstrate that the disease can be attacked with a conventional molecular treatment. In fact, Ivacaftor was found by screening thousands of drugs on a far less than ideal cell line. In the end, many drugs that functioned well on this cell line proved ineffective when used on genuine human airway tissue.
Genuine human airway tissue is the gold standard prior to drugs being tested clinically, but it has been extremely difficult to obtain the tissue from patients, and when it could be obtained, the tissue rarely survived long in the lab all of which created a major bottleneck in screening for a therapy. But by creating iPS cells that contain the entire genome of a CF patient and directing those cells to develop into lung progenitor cells, which then develop into epithelium, the group appears to have solved this key problem.
Rajagopal, who did his own postdoctoral fellowship in Melton's laboratory during the first half of the past decade after completing his training in pulmonary medicine, said that having both the G551D and 508 genes in the epithelial tissue provides a way to prove that the tissue will be effective in testing drugs against CF.
"We've created the perfect cell line to show that the drug out there that works against G551D mutation works in this system, and then we're in business to screen for a drug against delta 508," he said. "We'll know soon that the cell line works. We know it makes bonafide airway epithelium, and we'll have the proof of principle that the tissue responds properly to the only known drug. We think this is the near-ideal tissue platform to find a drug for the majority of CF."
Rajagopal's lab has created numerous other cell lines to further show that a CF drug that works in one patient should work in others and to see whether this will be an area that allows a more personalized approach to medicine.
"I'm most looking forward to working with the community of pulmonologists that concentrate in CF to generate therapies. This is occurring more than two decades after the remarkable work that identified the CF gene. Looking forward, I'm very excited that CF may lead the way in lung disease once more, by demonstrating that our iPS platform can be used to probe the diseases that are much less well understood. CF has more than two decades of great biology behind it. The reason we chose to attack this disease first was because of that pioneering work that lets us use our system with a very firm foundation," Rajagopal said.
###
The Harvard Stem Cell Institute is a collaborative of more than 1000 scientists throughout Harvard and its affiliated hospitals and Institutes, dedicated to using the fruits of stem cell biology to advance cures and treatments for human diseases and the degeneration associated with aging.
Massachusetts General Hospital (www.massgeneral.org), founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $750 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Hi. My name is Greg Marcel. I am a small business internet marketing consultant in Philadelphia.
My company is 2140 Interactive. Our niche is helping you market your niche through internet marketing. Because if no one can find you online, you don?t exist.
In the next few minutes I?m going to give you an overview of one form of internet marketing, social media marketing. I?ll explain why it is so important to your business, how to get started and what you can expect once you do.
Remember the not too distant past when the Yellow pages, newspapers and T.V. were the only games in town?
Those days are gone.
Today, when people are looking for information they go straight to the Internet. They do it at work, at home and even from their phone.
Did you know that there are 2 million Google Searches conducted every minute. Of those, 20% are related to location which means that 400,000 people are searching for local businesses every minute of every day!! And some of those people are searching for the type of product or service that you offer.
Social Media Marketing is a way for you to expose yourself to, and communicate with, those people on the Internet who are looking for exactly what it is you do.
How do I do that, you ask?
Here?s how.
There are thousands of websites online that make it really easy for the average person to get content on the Internet.
They include social networking sites like Facebook, Twitter and LinkedIn. Social bookmarking sites like Squidoo, Digg and Delicious. Social media sharing sites like YouTube, Viddler and Vimeo????. and many, many more.
You don?t have to deal with all of them though. In all, when we set up a social media campaign for a client, we establish a relationship with about 130 of the most popular search engine friendly websites.
So what do I do on these websites?
There?s really only a couple of things you need to do.
1. Provide quality content (so that people can find you). 2. Capture their information (so you can stay in touch with them). 3. Keep providing quality content (so that people get to know you, like you and trust you).
Provide quality content? You mean l should try and sell my quality stuff?.. right?
Actually, no! You provide quality content in the form of your expertise. You do this via blog posts, articles, podcasts and videos. You have a conversation with your online audience so that they get to learn more about you and what it is you do.
Hey this might come as a shocker but you do not make money with social media marketing!!! You make money by doing business with people who know, like and trust you.
You share your expertise with social media marketing. You build a strong foundation for your online relationships. You increase your visibility, which increases your referrals. You establish credibility, which demands higher prices. You build trust and position yourself as an expert in your field.
So build a strong foundation for your online image through a well thought out, effective and consistent social media marketing campaign.
Because if no one can find you online, you don?t exist.
I've always been the first one to say that getting any work done with a tablet of any kind isn't very practical. They're great for consumption, but production was something all-together different. I've changed my mind a little bit this week. I now have a Transformer Prime and keyboard dock, and have found that you can get some work done with an Android tablet, you just have to find the right tools. Hit the break, and I'll walk you through how I wrote this blog post (and others) with my Prime.
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Public release date: 5-Apr-2012
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