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Wednesday, February 22, 2012
Obama promotes modest American dream (AP)
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illustration friday :: fluid. - Jan Avellana | Hazelnut Cottage
{ her thoughts flowed :: digital illustration :: ? jan avellana, hazelnut cottage }
(illustration friday is an illustration website that highlights with a new word prompt every week. it is open to everyone?no jury, no clients, no limitations other than the theme for the week. come and join us!)
a quickie drawing in illustrator. if i had to choose between having to write or speak the rest of my life, i?d choose writing for sure. my words tend to flow so much more fluidly when i write than when i speak, especially in front of groups?oh, ick, public speaking is wayyy high up there on my AVOID list. my favorite part of this illustration? the bottle of ink! :D
Source: http://hazelnutcottage.typepad.com/hazelnut_cottage_design/2012/02/illustration-friday-fluid.html
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Tuesday, February 21, 2012
(CRWE, STV, SHS, UNF) Stock Report from CRWESelect.com ...
(CRWE, STV, SHS, UNF) Stock Report from CRWESelect.com
Crown Equity Holdings Inc. (CRWE) Crown Equity Holdings Inc. (CRWE.OB) www.crownequityholdings.com today announced that its subsidiary Crown Tele Services Inc. has entered into a letter of intent with MVOX AG. MVOX AG, located in Germany, will work with Crown Tele Services Inc. www.crownteleservices.com as a technological partner in offering wireless broadband solutions (wireless carrier class infrastructure in high speed data and WiMAX). Commenting on the Letter of Intent, "The keystone of our business has always been our commitment to meeting our customers' network needs and we will continue to grow with this principle," said Kenneth Bosket, Crown Tele Services Inc., President and CEO. About Crown Tele Services Inc. Crown Tele Services Inc. is a provider of affordable, world class (VoIP) communications solutions and is a subsidiary of Crown Equity Holdings Inc. For more information visit www.crownteleservices.com. About Crown Equity Holdings Inc. Crown Equity Holdings Inc. offers advertising branding and marketing services as a worldwide online multi-media publisher with its digital network of websites and focuses on the distribution of information for the purpose of bringing together a targeted audience and the advertisers that want to reach them. Its advertising services cover and connect a range of marketing specialties, as well as provide search engine optimization for clients interested in online media awareness. For more information visit www.crownequityholdings.com. About MVOX AG MVOX AG offers wireless broadband internet access services with over 15 years of experience as a system integrator, as well as being the most successful WiMAX operator in Germany. The company is based in Garching a.d. Alz, Germany. VoIP, or Voice Over Internet Protocol, is a service that uses the Internet to deliver voice communications. VoIP service is used as an alternative to traditional, line-based phone plans. Calls placed over the Internet are sent digitally, as data, and they are received by computers. This reduced the need for hardware and resulted in lower costs. One of the most significant benefits of VoIP technology is the low cost. In situations where broadband Internet is used for voice calls, the costs are typically dramatically lower than standard phone service. In fact, many VoIP services such as Skype and iCall cost nothing, as long as calls are made from one computer to another. When VoIP is used for calls to traditional phone lines, the cost remains low. Because the voice data is routed over existing Internet connections, the older phone infrastructure is bypassed. This method creates savings for the phone provider, who can pass on a lower price to the consumer. Crown Equity Holdings Inc., together with its digital network, currently provides electronic media services specializing in online publishing, which brings together targeted audiences and advertisers. Crown Equity Holdings Inc. offers internet media-driven advertising services, which covers and connects a range of marketing specialties, as well as search engine optimization for clients interested in online media awareness. For more information, please visit their website: http://www.crownequityholdings.com ******************************************* China Digital TV Holding Co. Ltd. (NYSE:STV) announced it will report its unaudited financial results for the fourth quarter and fiscal year ended December 31, 2011, after the U.S. market closes on Wednesday, February 29, 2012. China Digital TV's management will host an earnings conference call at 7:00 p.m. on Wednesday, February 29, 2012 U.S. Eastern Time (8:00 a.m. on March 1, 2012 Beijing/Hong Kong Time). Conference Call Dial-in Information, United States Toll Free: +1-866-519-4004, International: +1-718-354-1231, Hong Kong: +852-2475-0994. China Digital TV Holding Co. Ltd., through its subsidiaries, provides conditional access (CA) systems to the digital television market in the People's Republic of China. ******************************************* Sauer-Danfoss Inc. (NYSE:SHS) announced that it will be holding a conference call on March 1, 2012, at 10:00 AM Eastern time. The purpose of the call will be to discuss fourth quarter 2011 results. The Company will release fourth quarter results the previous day, after the close of markets. The call is open to all interested parties on listen-only mode via an audio webcast and can be accessed through the Investor Relations page of the Company's website at http://ir.sauer-danfoss.com. A replay of the call will be available at that site through March 15, 2012. If you would like to participate in the live conference call so that you may ask questions, please contact us for the call-in number. Sauer-Danfoss Inc. designs, manufactures, and markets hydraulic, electronic, and mechanical components, as well as software and integrated systems that generate, transmit, and control power in mobile equipment. ******************************************* UniFirst Corporation (NYSE:UNF) announced that Ronald D. Croatti, President and Chief Executive Officer, and Steven S. Sintros, Vice President and Chief Financial Officer, will speak at 9:10 a.m. Eastern Time on February 29, 2012 at the Robert W. Baird Business Solutions Conference. The conference is being held at the Four Seasons Hotel in Boston, MA where UniFirst will discuss business highlights as well as information concerning recent business trends. UniFirst Corporation, together with its subsidiaries, provides workplace uniforms and protective work wear clothing in the United States, Canada, and Europe. CRWESelect, a stock highlight publication is pleased to alert investors of stocks on the move. Sign Up for our Free Stock Newsletter at http://www.crweselect.com/signup ******************* THIS IS NOT A RECOMMENDATION TO BUY OR SELL ANY SECURITY! Disclaimer: Never invest in any stock featured on our site or emails unless you can afford to lose your entire investment. CRWESelect.com publisher and its affiliates and contractors are not registered investment advisers or broker/dealers.Our disclaimer( http://crweselect.com/disclaimer) is to be read and fully understood before using our site, reading our newsletter or joining our email list. Release of Liability: Through use of this website viewing or using, you agree to hold CRWESelect.com report and Crown Equity Holdings Inc. CRWE, its operators, shareholders, employees and/or contractors harmless and to completely release them from any and all liability due to any and all loss (monetary or otherwise), damages (monetary or otherwise) that you may occur. Rule 17B requires disclosure of payment for investor relations. Crown Equity Holdings Inc. (CRWE.OB) is a media-advertisement and newswire company. Crown Equity Holdings Inc. (CRWE.OB), in some cases, provides media advertising and public awareness for both public and private companies, as well as disseminating news. As such, in some cases, when Crown Equity Holdings Inc. (CRWE.OB) advertises for a particular client, Crown Equity Holdings Inc. (CRWE.OB) charges an advertising fee which it must disclose under 17B. The fee may be in cash, in free trading stock or in restricted stock. Crown Equity Holdings Inc. (CRWE.OB), if paid in stock, can and may sell those securities during the advertising period.
Source: http://crweselect1.posterous.com/crwe-stv-shs-unf-stock-report-from-crweselect-78870
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Understanding Breast Cancer Responsiveness
Dr. Karen Gelmon (biography and disclosures)
What I did before
When I started treating breast cancer, systemic therapy recommendations were usually based only on the menopausal status of the woman and whether there was cancer in the axillary nodes.? Although estrogen status was being measured the importance of this marker was not appreciated.
What changed my practice
In the last decade there has been an explosion of information about the genetics and molecular makeup of breast cancers with a heightened understanding that breast cancer is not one disease. A landmark publication in 2000 described four types of breast cancer. 1 In a recent as yet unpublished study using newer sequencing technology, researchers at the BC Cancer Agency and collaborators from the UK have suggested 9 distinctive types of the disease. 2 ?The recognition of these subtypes of breast cancer is changing how we approach and treat the disease.
The risk of recurrence is a major concern when an early breast cancer is diagnosed as even with excellent surgery there is a risk of both local and systemic recurrence.? Architectural factors such as the size of the tumour and nodal involvement have classically been used to determine risk. Biological features such as estrogen receptor status, HER2 expression and grade, often measured by Ki67, are now being included in our risk assessment.
The responsiveness of the tumour has also become an important determinant in how we treat the disease.? Responsiveness describes how the tumour will be affected by specific treatments.?? For example, estrogen receptor status determines whether a breast cancer will respond to endocrine therapy; the gene HER2 is associated with response to anti HER2 therapy such as trastuzumab (Herceptin); and high KI67 tumours may be more responsive to chemotherapy than those with a lower grade or KI67.? Thus two similar sized tumours may get different treatment recommendations based on their biology.
What I do now
For patients with low grade estrogen receptor positive tumours I am recommending much less chemotherapy even if there is nodal involvement and/or the woman is premenopausal.? In these tumours, endocrine therapy may be the most effective treatment and chemotherapy may minimally impact survival.? Having said that, some patients still benefit from including chemotherapy in addition to hormone therapy.? For patients with HER2 overexpressing tumours I often recommend chemotherapy and trastuzumab even if the tumour is small with no involved nodes.? Understanding the biology of breast cancers is providing more personalized recommendations and this is translating into better outcomes.
As we further define subtypes, more targeted treatments will be developed but at this time for many cancers we continue to give broad cytotoxic therapy.? As well, new agents are being developed and may be further decrease recurrences. We are also now frequently rebiopsying recurrent cancers to further understand the markers of response and resistance and to tailor treatment. We also need to study the ?host? patient, as the pharmacogenomics of the individual may affect how the drug is metabolized and also may contribute to the effectiveness and the toxicity of the therapy.
How does this affect family physicians?? Treatment recommendations may be more complicated so counseling patients prior to their oncological consultation may be more confusing.? It may be more difficult to know whether chemotherapy will be recommended or not especially if we begin to do more complex assessments of tumours in specialized laboratories. Numerous studies are reported in the lay and academic press and are never substantiated.? Understanding what is of relevance to the care and management of our patients and which data is transient is difficult.? We need to ensure that the government prioritizes an upgrade of our electronic BC Cancer Agency website and electronic record to make it accessible to primary health care providers with the appropriate, evidence based results.
Biological information is often available as soon as the core biopsy diagnoses an invasive cancer.? Early referral to centres with multidisciplinary teams may avoid long delays and confusing information for both the patient and the primary care providers.? Electronic integrated systems may also aid the transfer of information. Frequent updates at family practice meetings and in journals can also provide current treatment and care models to a wider audience.? With this knowledge, family practices can provide a broad idea of the concept of adjuvant therapy for the treatment of early breast cancer and introduce the idea of chemotherapy, hormones and radiation without specifying the details.? Family doctors should be aware of the new patient package, including a patient book that is available through the Alliance for Breast Cancer Information at the BC Cancer Agency. 3 Reassuring patients about the improvements in survival as over 90% of early breast cancer cases in BC now live over 5 years will also help provide helpful information to decrease a woman?s anxiety. 4
References (Note: Article requests require a login ID with CPSBC or UBC)
- Perou CM, Sorlie T, Eisen MB, et al.? Molecular portraits of human breast tumours.? Nature 2000; 406 (6797): 747-52 (View article with CPSBC or UBC)
- Personal communication with Dr Samuel Aparicio
- Alliance for Breast Cancer Information BC, 604 707 5818, and Intelligent Patient Guide ? Olivotto, Gelmon, McCready, 5th edition, 2011 (book)
- Coleman MP, Forman D, Bryant H et all.? Cancer survival in Australia, Canada, Denmark, Norway, Sweden and the UK, 1995-2007 (the international cancer benchmarking partnership): an analysis of population ?based cancer registry data.? Lancet 2011; 377(9760): 127-138. (View article with CPSBC or UBC)
UBC CPD Cancer Care Outreach Program on Education (CCOPE)
Over the past 4 months, UBC CPD has been delivering case-based workshops on breast cancer care to various communities in BC, the last workshop is scheduled for Dawson Creek on March 28th.? Workshop contents covers screening guidelines, diagnostic procedures, main treatment options and their potential side effects, and follow-up of breast cancer patients.
Read more about the UBC CPD Cancer Care Outreach Program on Education (CCOPE) .
Read more about CCOPE ? Breast Cancer Community Workshops.
Source: http://thischangedmypractice.com/2012/02/20/breast-cancer-responsiveness/
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Monday, February 20, 2012
Japan's record trade deficit highlights weakening Chinese demand (Reuters)
[unable to retrieve full-text content]Reuters - Japan logged a record trade deficit with China in January as exports dropped by a fifth, underscoring concerns about how sharply China is slowing and its ability to buffer a frail global economy against European turmoil.
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Gig reports: The Word House / We Are Poets and Grand Verse ...
February 18, 2012 by Dan Simpson
I comp?red two seemingly disparate but equally delightful gigs this week.
Emma Jones opened the show with her trademark impersonations and well-observed humour; Anthony Anaxagorou brought a fierce but controlled intensity to proceedings; Dean Atta captured the mood of the moment with his well-constructed set. The open mic was a mixture of established names and newcomers who all went down well with a warm Word House crowd, but the real treat was the presence of Kadish Morris and Saju Ahmed. These two poets were part of the Leeds Young Authors cohort that featured in We Are Poets, and their poems demonstrated why they were the subject of the film.
Huge thanks to the makers of We Are Poets for the gig, the Curzon Cinema Soho for hosting an excitingly cross-artform event and of course all the people who saw the film and stayed for the Word House. The next Word House is in April ? like us on Facebook for more!
On Thursday I was in Margate for Grand Verse Quarto. Game Expo East Kent (GEEK) included a performing arts fringe, and I decided that an evening of videogame inspired poetry was in order. Apples and Snakes and the Tom Thumb Theatre thought so too, so Ross Sutherland, Jacob Sam-La Rose, Christian Watson and I formed a quartet to bring some spoken word to the gamers.
GEEK itself was great fun as I got to have a go on retro versions of Street Fighter and lose to far-too-quick teenagers on Halo 2. The best bit though was listening to a panel discussion featuring indie game developers. It turns out that some of the things that affect poets, writers ? and, I suspect, anyone working as an artistic practitioner ? similarly trouble games makers. Topics raised that struck a chord with me included issues surrounding sourcing funding and making a living from the medium you love; the difficulties and challenges of competition; and a classic one: spending time on promotion and marketing when you want to be making.
Byron Atkinson-Jones, who runs indie game developer?Xiotex Studios, took some brilliant photos of the event, which can be found below. He also left some lovely feedback about the gig:
?I had always thought that such things were the domain of stuffy intellectual types but I had an amazing time and am now craving more. The skill behind the words and the delivery with emotion was stunning.?
So, both of these gigs this week did one of the things that motivates me as a poetry practitioner and project event organiser type: exposing new audiences to high quality spoken word, demonstrating the strength and flexibility of the medium. Two very different evenings, many interesting parallels, one wonderful artform that unites them.
- Dan
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Sunday, February 19, 2012
GoodRx Grabs $1M+ From SV Angel, Founders Fund & More To Help You Find Cheap Prescription Drugs
Like many other services, goods, and commodities, prescription drug prices can vary widely depending on location and what particular vendor is offering them. Launching last September at the Health 2.0 Conference in San Francisco was GoodRx, a service that's aiming to bring some transparency back to prescription drug purchases by bringing some sophisticated price comparison technology to the everyday consumer. GoodRx was co-founded by Scott Marlette and Doug Hirsch, both early employees of Facebook. Hirsch was VP of Product at Facebook back in 2005, and Marlette, one of the company's first 20 employees, was an engineer who worked on, among other things, Facebook's photo application. The culture of transparency, openness, and focus on the big picture, Marlette says, had a lasting influence on him after Facebook, leading he and Hirsch to apply some of that psychology to building a better way to serve consumers with the latest pricing info from the prescription drug market.Source: http://feedproxy.google.com/~r/Techcrunch/~3/mdaiQbOIjUc/
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